VLDL triglyceride levels are elevated by low fat, high carbohydrate diets

This study was published in the Journal of Clinical Investigation 1996 May 1; 97(9): 2081–2091.

Study title and authors:
Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet.
L C Hudgins, M Hellerstein, C Seidman, R Neese, J Diakun, and J Hirsch
Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, NY 10021, USA. hudgins@rockvax.rockefeller.educ

This paper can be accessed at:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507283/

This study sought to find out if a low fat or a high fat diet raised the "bad" very low density lipoprotein (VLDL) triglyceride levels.

For 25 days subjects consumed either:
(i) Low fat liquid formula diets (10% of calories as fat and 75% as glucose polymers)
(ii) High fat diets (40% of calories as fat and 45% as glucose polymers)

This Study founds eating low fat, high carbohydrate diets increases 'bad' cholesterol VLDL triglyceride levels. Eating a high fat diet has virtually no effect on VLDL triglyceride levels. Hudgins notes that high VLDL triglyceride levels are associated with heart disease.

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